Askep Kanker Endometrium Pdf Software5/30/2023 ![]() Additionally, we discovered that RANK/RANKL promoted EC cell proliferation, migration and invasion, which was correlated with the activated mitogen-activated protein kinase (MAPK) pathway. ![]() The higher RANK expression in human EC was associated with myometrial invasion, lymph node metastasis and lymphovascular space involvement. In the present study, we showed that RANK/RANKL was aberrantly overexpressed in human EC tissues. In the present study, we performed the first investigation of the relationship between RANK/RANKL expression in EC tissues and clinicopathological features. We evaluated whether targeting of RANKL might be an efficient therapeutic strategy in EC. However, the exact function and mechanism of RANKL in human endometrial cancer (EC), particularly in progesterone-resistant and aggressive EC, remain unclear. The targeting of receptor activator of nuclear factor-κB ligand (RANKL) is being increasingly investigated as a potential therapeutic strategy in several types of cancers.
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